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The History Behind The Pill
Phentermine is associated with a rich and long history within the pharmaceutical industries which formed a portion of a weight-loss plan that is medically managed. Since 1959, physicians turned to this medication to assist in reducing the appetites in obese patients and for promoting calorie reduction. While it is still available in certain forms, the history of this drug is troubled, which is why it is now classified as a type of controlled substance when it comes to the majority of countries.
Made Available In The Year 1959
The drug known as phentermine was first introduced onto the markets in the latter part of the 1950s. The U.S FDA (Food and Drug Administration) approved its use for treating obesity. The drug was also classified as the safer alternative to the “Rainbow pills” that were used up until this point which involved cocktails of diuretics, digitalis, thyroid hormone, and amphetamine which was often linked with a number of severe complications.
The Weight Loss Trends In The 1970s
It became more known in the 1970s, along with two other drugs with FDA approval. The cocktail known as Fen-Phen involved a phentermine dose combined with a dose of fenfluramine, which is a type of serotonin-releasing agent. At this stage, the FDA did not give approval to mixing these medications, but doctors still prescribed both drugs together to their patients for the purposes of weight loss.
Dexfen-Phen provided a similar type of offering but was a combination that paired dexfenfluramine and phentermine in order to manage weight problems such as obesity. Dexfenfluramine received approval from the FDA in 1996, and also works on reducing the appetite. When combined with phentermine, patients would eat less along with sustaining higher energy levels. These drug cocktails did not last long, due to the health concerns associated with combining the different drugs.
Some of the risks involved with combining these drugs resulted in a few findings:
– In the year 1997, scientists from the Mayo Clinic linked 24 heart-valve disease cases to using Fen-Phen.
– Further connections were then made between using dexfenfluramine and fenfluramine to various types of heart-valve complications. Researchers discovered that 30% of patients that were evaluated had used either dexfenfluramine or fenfluramine at the same time as phentermine.
– By July 1997, the FDA went on an issue with an advisory that reported the relationship between heart-valve diseases and the Fen-Phen cocktail.
This later resulted in the FDA requesting that the pharmaceutical companies remove dexfenfluramine and fenfluramine voluntarily from the markets. However, phentermine remained available.
The Introduction Of Phen-Pro
Today, doctors now have another weight-loss cocktail on offer which combines antidepressants such as Effexor, Zoloft, or Prozac with phentermine. The antidepressants are what allows for a benefit to taking the pills so that it lasts for longer.
When taken on its own, the effects usually wear off quickly, which means the medication is only effective over a shorter time. The FDA has not yet approved using these medications together, but at this stage, there isn’t any evidence that this combination could result in health issues like the ones from the previous “phen” cocktails.
How Does It Work?
It is classified as one of the central nervous stimulants that are often used for treating obesity. The experts are still not exactly certain how this drug works, yet it appears to offer multiple actions that include stimulating the neurons into releasing neurotransmitters norepinephrine and dopamine which is what is believed to account for the appetite-suppressing effects.
This drug is also said to increase the levels of serotonin, dopamine, and norepinephrine in the way of inhibiting the reuptake, as well as inhibiting the monoamine-oxidase enzymes. Phentermine is classified in the group of drugs that are known as anorexigenics or anorectics.
The Benefits After Buying
– Can be used over the short-term as a tool for weight-loss when added with exercise, caloric restrictions, and behavioral modifications. This medication is only suggested for people that have an initial BMI of either equal to or more than 30kg/m2 or 27kg/m2 along with risk factors for cardiovascular events like diabetes, high cholesterol, and high blood pressure.
For patients between the age of 18 to 60 that are not on any other medications or have no known medical conditions, the side-effects that the person will probably experience can include:
– High blood pressure or other types of cardiovascular effects are adverse. This can include sexual dysfunction, rash, dry mouth, psychosis, headaches, insomnia, and gastrointestinal disturbances.
– The treatment that extends past two weeks or more increases the risks of dependence and addiction to phentermine. Abrupt cessation after prolonged dosing can result in withdrawal effects such as depression and extreme fatigue.
– Can impair judgment as well as affect the person’s abilities to operate machinery or drive.
– A tolerance might develop to weight-loss effects associated with the pills, which will render the treatment less effective.
– Is not advised for use in children that are 16 years of age or younger.
– The fat burner is the type of medication that is never suitable for individuals with histories associated with hyperthyroidism, glaucoma, cardiovascular diseases, or a history linked to drug abuse. It is also not suitable for mothers who are breastfeeding or pregnant.
– The fat burner can interact with various other types of drugs which include other drugs that are used for the purpose of weight loss which will include both over-the-counter preparations or prescribed products and even herbal supplements.
It should also not be taken with antidiabetic, antipsychotics, or antidepressant drugs, or any other types of central-nervous-system stimulants. A few of these interactions could become potentially fatal like phentermine combined with dexfenfluramine or fenfluramine.
It is advised for use for a short-term treatment plan as an aid for treating patients that are obese to lose weight. It is important to consider that the medication can become addictive or tolerance to the drug might develop when it comes to its overall weight-losing effects. If this occurs, the medication will become less and less effective over time.